Things You Need to Know About Monoamine Oxidase

Monoamine oxidase inhibitors are amongst the oldest kinds of antidepressants still being used. Since there are extra options readily available, MAOIs are not utilized as commonly as they need to be utilized.

MAOIs can connect with plenty of various other medicines, which makes them awkward together with other medicines. You normally need to not take MAOI for about two weeks prior to beginning another antidepressant. They can additionally set off allergies to specific foods, so getting on them commonly involves nutritional restrictions.

Still, MAOIs can be helpful if other types of antidepressants haven’t functioned. They are in some cases used to deal with a bipolar affective disorder or to deal with neurological conditions, such as Parkinson’s disease.

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They can also be practical with atypical clinical depression, or “depression with irregular attributes.” In addition to the regular signs of depression, these “atypical functions” are:

Raised hunger or weight gain

A sense of heaviness in the limbs or “leaden paralysis”

Resting way too much

Being incredibly sensitive to social rejection

Other possible signs of atypical depression include:

  • Intensely food craving focus
  • Enhanced libido
  • Anxiety attack
  • Instances of MAOIs

Common name or Brand name:

  • Isocarboxazid or Marplan
  • Selegiline or EMSAM
  • Phenelzine or Nardil
  • Tranylcypromine or Parnate

EMSAM is unique amongst MAOIs and other antidepressants. As opposed to a tablet, it is taken as a skin spot. There is some evidence that it might be more efficient as well as have fewer adverse effects than other MAOIs.

How do MAOIs work?

Like various psychological health drugs, MAOIs function by recovering the equilibrium of the chemicals in your mind. These chemicals are called neurotransmitters. The major natural chemicals impacted by antidepressants are:

  • Serotonin, which impacts your power level, state of mind, appetite, as well as rest.
  • Dopamine, which impacts satisfaction and inspiration, is occasionally called the “feel-good chemical.”
  • Norepinephrine, which affects your emphasis, power level, as well as interest. Related to adrenaline and has comparable effects.
  • Most antidepressants improve serotonin levels. MAOIs boost all three. In fact, MAOIs helped researchers discover how these chemicals are involved in anxiety in the first place.

Side Effects of MAOIs:


  • Fainting and Dizziness
  • Nausea
  • Difficulty sleeping, or sleepiness

Less Usual:

  • Weight gain
  • Problem getting to orgasm or reduced libido
  • Involuntary muscle jerks or muscle mass aches
  • High blood pressure
  • Serotonin syndrome
  • Tingling or prickling feeling in the skin, or paresthesia