CJC-1295 is a synthesized peptide which is an analogue of GHRH or Growth Hormone Releasing Factor. This peptide is capable of enhancing IGF-1 or insulin like growth factor and growth hormone plasma level in the blood. The only problem with CJC-1295 is its short half-life. The addition of DAC or Drug Affinity Complex increases the half-life of this combination. Researchers have synthesized quite a few modifications of GHRH over the years. These modified peptides eliminate some of the hormone’s traits while retain others. CJC-1295 is one of these analogues and it has the first 29 amino acids of Growth Hormone Releasing Hormone. As it is derived from the first 29 amino acids just like Sermorelin, CJC-1295 DAC shares some similarities to it as well. Though not identical, but it is also closest to Modified GRF.
A lysin linker attaches DAC to CJC-1295. It protects the peptide in the bloodstream during circulation. DAC improves the half life by associating the peptides with albumin and other blood proteins. This association increases the half-life of CJC-1295. Conjuchem Biotechnologies addressed DAC conjugated CJC-1295 as the only CJC-1295. The variant without DAC is also being sold under the same name. It always leads to a certain level of confusion. Licensed researchers can get cjc 1295 dac for sale for laboratory purpose.
Growth hormone release and the role of CJC-1295 DAC
Growth Hormone plays an important part in human body can be a great part in treating and improving various conditions. As CJC-1295 DAC is an analogue to natural Growth Hormone Releasing Hormone, it helps to trigger the release natural GH in animal body. When administered on mice models, the Growth Hormone production was 2-10 timers higher. The expression of GH reaches its maximum point after 2 hours of administering. Its effects remain up to six days. CJC-1295 DAC helps to maintain natural GH level just like natural GHRH which cannot be achieved with other secretagogues. As the physiological level is maintained, this peptide helps to enjoy the benefits of GH without triggering its side effects.
Effects on infertility
Studies from as early as 1990s indicate towards positive effects of CJC-1295 DAC on female fertility. Just like other GRF analogues, this peptide also improves fertility. Researches on mice models show that the level of IGF-1 and GH gets increased in blood around the time of ovulation. This indicates towards the possibility of including GRF analogues and CJC-1295 DAC in treating female patients to improve ovulation. This might be possible due to the GH and IGF-1 expression cycle. Scientists have also suggested about its use in improving male fertility. But this hypothesis is yet to be proved.
Effects on growth
As CJC-1295 DAC is capable of helping in maintaining natural level of GH, it can be a part of treating growth anomalies in patients lacking natural level of GH. Research on mice models suggest that the use of this peptide on mammals including humans can bring success. The interest about this peptide has increased due to its potential capability to treat infertility.